Tripeptide-29 (Collagen Tripeptide, Oligopeptide-29) – ≥98% purity biomimetic peptide. Gly-Pro-Hyp sequence mirrors native collagen fragment. Stimulates collagen I synthesis, reduces wrinkles, improves elasticity & hydration. Ideal for anti-aging serums, creams & eye care. Request samples!
Product Title / 产品名称
Tripeptide-29 (Collagen Tripeptide / Oligopeptide-29) | ≥98% Biomimetic Signal Peptide for Anti-Aging Formulations
Product Name: Tripeptide-29 / Oligopeptide-29 / Collagen Tripeptide
INCI Name: Tripeptide-29
CAS No.: 2239-67-0
Molecular Formula: C₁₂H₁₉N₃O₅
Molecular Weight: 285.3 g/mol
Amino Acid Sequence: H-Gly-Pro-Hyp-OH (Glycine-Proline-Hydroxyproline)
Purity: ≥98.0% (HPLC)
Appearance: Off-white to white powder
Grade: Cosmetic Grade
Shelf Life: 24 months
Product Overview
Tripeptide-29, also known as Collagen Tripeptide or Oligopeptide-29, is a biomimetic peptide composed of three amino acids — Glycine, Proline, and Hydroxyproline (Gly-Pro-Hyp) . This specific sequence is the most abundant repeating fragment found in human type I collagen, making it a highly targeted and effective signal peptide for skin regeneration .
As a collagen-derived peptide, Tripeptide-29 functions as a matrikine — a bioactive fragment that mimics the body‘s natural collagen breakdown signals to stimulate new collagen production . Its small molecular weight (285.3 Da) enables superior transdermal penetration, with studies demonstrating 78.3% permeation in ex vivo skin models at 0.05% concentration .
Key Specifications
| Parameter |
Specification |
| Product Name |
Tripeptide-29 / Oligopeptide-29 |
| Synonyms |
Collagen Tripeptide, H-Gly-Pro-Hyp-OH |
| CAS No. |
2239-67-0 |
| Molecular Formula |
C₁₂H₁₉N₃O₅ |
| Molecular Weight |
285.3 g/mol |
| Amino Acid Sequence |
H-Gly-Pro-Hyp-OH |
| Purity |
≥98.0% (HPLC) |
| Appearance |
Off-white to white powder |
| Boiling Point |
629.8 ± 55.0 °C (Predicted) |
| Density |
1.493 ± 0.06 g/cm³ (Predicted) |
| Solubility |
Soluble in DMSO (slightly), methanol (slightly), water (slightly, with ultrasonication) |
| Particle Size |
Passes 80-mesh sieve |
| Grade |
Cosmetic Grade |
| Storage |
Sealed, protected from light, stored in cool, dry, well-ventilated area |
| Packaging |
1g, 10g, 100g, 1kg/aluminum foil bag; 25kg/fiber drum; custom available |
| Shelf Life |
24 months |
Key Benefits
| Benefit |
Description |
| Collagen Stimulation |
Activates TGF-β/Smad signaling to boost type I collagen synthesis; up to 400% increase in fibroblast activity |
| Wrinkle Reduction |
Minimizes the appearance of fine lines and deep wrinkles
|
| Anti-Photoaging |
Reduces MMP-1/MMP-3 levels, protecting against UVB-induced collagen degradation |
| Skin Firming & Elasticity |
Enhances skin firmness and overall elasticity
|
| Hydration Boost |
Increases skin hydration by up to 23% through barrier enhancement
|
| Texture Improvement |
Improves uneven skin texture and reverses dehydrated appearance
|
| Barrier Restoration |
Strengthens skin‘s supportive elements and restores barrier function
|
| Gentle & Well-Tolerated |
No irritation observed at 0.01%–0.5% over 28 days (ISO 10993) |
Clinical Validation & Regulatory Status
Permeation Efficiency: 78.3% skin permeation at 0.05% concentration in ex vivo models (Journal of Cosmetic Science, 2020)
Safety Confirmed: Non-irritating reactions in 28-day cumulative irritation tests at 0.01%–0.5% (ISO 10993 standard)
Clinical Efficacy: 4-week clinical study on a formulation containing 0.1% Tripeptide-29 demonstrated significant improvements in skin hydration and texture
Application Scenarios
| Application |
Typical Formats |
Recommended Usage |
| Anti-Aging Serums & Essences |
Water-based serums, ampoules, concentrates |
0.1% – 1.0%
|
| Firming & Lifting Creams |
Day creams, night creams, moisturizers |
0.1% – 0.5% |
| Eye Contour Treatments |
Eye creams, eye serums, eye gels |
0.1% – 0.5%
|
| Sheet Masks & Hydrogel Patches |
Face masks, eye patches |
0.05% – 0.3% |
| Premium Anti-Aging Concentrates |
High-performance treatment products |
0.1% – 0.3%
|
| After-Sun & Recovery Products |
Soothing gels, recovery balms |
0.1% – 0.5% |
| Makeup Primers |
Primer formulations |
0.1% – 0.5% |
| Facial Creams & Lotions |
Emulsions, lotions |
0.1% – 0.5% |
Formulation Notes:
Optimal pH Range: 5.5 – 6.5 for maximum stability (95% activity retention)
Synergistic Combinations: Works synergistically with hydrolyzed collagen and hyaluronic acid cross-polymers (1.8x increase in collagen deposition)
Avoid: High concentrations of ethanol which may compromise peptide stability
Packaging & Storage
| Packaging Option |
Specification |
| Sample / Trial |
1g, 10g, 100g per aluminum foil bag |
| Standard |
1kg per aluminum foil bag |
| Bulk |
25kg per fiber drum |
| Custom |
Available upon request |
Storage Conditions: Keep sealed, protected from light, and store in a cool, dry, well-ventilated area.
Shelf Life: 24 months from date of manufacture when stored properly.
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