| Product Name |
Recombinant Collagen (Type VI) |
| Product Specification |
10g/bag |
| Endotoxin |
≤0.5EU/mg |
| Performance Advantages |
E.coli Expression
No repeats, long sequence
Multiple functional sites
Low-temperature freeze-dried
No glycosylation modifications
Purity ≥99% |
| Application Scope |
Anti-Aging Implant Fillers
Bio-Coatings
Hair Regrowth & Anti-Hair Loss |
Advance your hair regeneration and skin rejuvenation research with our premium Recombinant Human Collagen Type VI. As a unique beaded filament-forming collagen, Type VI assembles into microfibrillar networks that anchor cells to the extracellular matrix and play critical roles in hair follicle stem cell niche maintenance, melanocyte survival, and dermal homeostasis .
Produced via a precise E. coli expression system, our Type VI collagen features:
Native Microfibrillar Structure: Long-chain sequence with multiple functional epitopes for cell-matrix interactions.
Ultra-Low Endotoxin: ≤0.5 EU/mg, ensuring safety for sensitive in-vivo applications.
Exceptional Purity: >99% via HPLC, free from animal-derived contaminants.
No Glycosylation Modifications: Ensures consistent, reproducible bioactivity.
Key Scientific Background – Hair Biology:
Melanocyte Maintenance: Recent groundbreaking research demonstrates that the COL6A3-CD44 signaling pathway from dermal fibroblasts to melanocytes promotes the early maintenance of organotypic melanocytes during skin organoid culture. This pathway is essential for establishing pigmented hair patterns .
Hair Follicle Stem Cell Niche: Type VI collagen provides structural support to the bulge region, where hair follicle stem cells reside, regulating their activation and quiescence .
Hair Pigmentation Control: Through its interaction with melanocyte progenitors, Type VI collagen influences the adaptive patterning of melanocytes within the hair follicle, ultimately enhancing hair pigmentation .
Additional Applications:
Anti-Aging Implant Fillers: Type VI collagen is a key target in biostimulatory fillers; recent studies show that dermal fillers can significantly stimulate Type VI collagen production alongside Types I, III, and IV, contributing to comprehensive extracellular matrix regeneration .
Biocoatings: Provides a native-like microenvironment for cell attachment and proliferation on medical devices.
Supplied as cryo-dried powder in 10g/bag packaging. Ideal for R&D into hair loss therapies, melanocyte regeneration, and next-generation dermal fillers.
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