| Product Name |
Recombinant Collagen (Type V) |
| Product Specification |
10g/bag |
| Endotoxin |
≤0.5EU/mg |
| Performance Advantages |
E.coli Expression
No repeats, long sequence
Multiple functional sites
Low-temperature freeze-dried
No glycosylation modifications
Purity ≥99% |
| Application Scope |
Scar Removal Products
Pet Healthcare
Wound Dressings |
Advance your scar management and wound healing portfolio with our premium Recombinant Human Collagen Type V. As a regulatory fibril-forming collagen, Type V plays a critical role in controlling collagen fibril diameter and assembly by co-assembling with Type I collagen into heterotypic fibrils . This unique regulatory function makes it essential for developing products that minimize scar formation and promote physiologic tissue repair.
Produced via a precise E. coli expression system, our Type V collagen features:
Native Regulatory Function: Long-chain sequence with retained N-propeptide domains required for fibril diameter control .
Ultra-Low Endotoxin: ≤0.5 EU/mg, ensuring safety for in-vivo applications.
Exceptional Purity: >99% via HPLC, free from animal-derived contaminants.
No Glycosylation Modifications: Ensures consistent, reproducible bioactivity.
Key Scientific Background:
Fibrillogenesis Regulation: Type V collagen controls the initiation of collagen fibril assembly; its deficiency leads to structurally abnormal, large-diameter fibrils associated with poor tissue outcomes .
Scar Size Limitation: Recent studies demonstrate that Type V collagen limits fibrotic scar size by regulating integrin-dependent fibroblast activation; deletion of Type V collagen results in a 1.5-fold increase in scar area .
Granulation Tissue Association: Type V collagen is strongly expressed in blood vessel walls during wound healing and synthesized by fibroblast-like cells in granulation tissue .
Anti-Angiogenic Potential: The HEPV fragment of Type V collagen α1 chain contains a heparin-binding site that can inhibit FGF-2-induced angiogenesis, offering potential for controlling aberrant vascularization in scars .
Primary Applications:
Scar Reduction Products: Formulations that promote physiologic fibril assembly and limit hypertrophic scarring.
Advanced Wound Dressings: Supports organized matrix deposition and reduces fibrotic outcomes.
Veterinary Regenerative Medicine: Enhances soft tissue repair with reduced scar formation in companion animals.
Supplied as cryo-dried powder in 10g/bag packaging. Ideal for R&D into next-generation scar management and wound healing products.
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