Palmitoyl Tripeptide-1 (Pal-GHK) – ≥98% purity matrikine signal peptide. Stimulates type I & III collagen, elastin & GAG synthesis. Clinically proven to reduce wrinkle depth by 23% & length by 39% in 4 weeks. Ideal for anti-aging serums, creams & eye treatments. Request samples!
Product Title
Palmitoyl Tripeptide-1 (Pal-GHK) | ≥98% Matrikine Signal Peptide for Advanced Anti-Aging Formulations
Product Name: Palmitoyl Tripeptide-1
Synonyms: Pal-GHK, Palmitoyl Oligopeptide, C16-GHK, C16-GK-3
INCI Name: Palmitoyl Tripeptide-1
CAS No.: 147732-56-7
Molecular Formula: C₃₀H₅₄N₆O₅
Molecular Weight: 578.79 g/mol
Amino Acid Sequence: Pal-Gly-His-Lys-OH (Pal-GHK)
Purity: ≥98%
Appearance: White powder
Grade: Cosmetic Grade
Shelf Life: 24 months
Product Overview
Palmitoyl Tripeptide-1 (Pal-GHK) is one of the most extensively researched and commercially successful signal peptides in cosmetic science. It is a synthetic peptide composed of three amino acids — glycine, histidine, and lysine (GHK) — chemically linked to palmitic acid, a fatty acid that significantly enhances its lipophilicity and transdermal penetration.
This peptide is the collagen-building half of the renowned Matrixyl 3000 complex (alongside Palmitoyl Tetrapeptide-7), a gold-standard anti-aging ingredient used by leading global brands. As a matrikine signal peptide, Palmitoyl Tripeptide-1 mimics a fragment of Type I collagen. When endogenous collagen degrades, similar peptide fragments naturally signal fibroblasts to synthesize new structural proteins. By supplying this peptide topically, we directly activate this signaling cascade, encouraging fibroblasts to rebuild the dermal matrix.
Our Palmitoyl Tripeptide-1 is manufactured to ≥98% purity with strict quality control, offering formulators a high-potency, clinically validated active ingredient for premium anti-aging skincare products.
Key Specifications
| Parameter |
Specification |
| Product Name |
Palmitoyl Tripeptide-1 |
| Synonyms |
Pal-GHK, Palmitoyl Oligopeptide, C16-GHK |
| INCI Name |
Palmitoyl Tripeptide-1 |
| CAS No. |
147732-56-7 |
| Molecular Formula |
C₃₀H₅₄N₆O₅ |
| Molecular Weight |
578.79 g/mol |
| Amino Acid Sequence |
Pal-Gly-His-Lys-OH |
| Purity |
≥98% |
| Appearance |
White powder |
| Grade |
Cosmetic Grade |
| Solubility |
Water-soluble |
| Recommended Usage |
≤0.001% (up to 5% in some formulations) |
| Storage |
Sealed, protected from light, stored in cool, dry, well-ventilated area |
| Packaging |
1g/bag, 1kg/aluminum foil bag, 10kg/carton, 25kg/fiber drum; custom available |
| Shelf Life |
24 months |
Mechanism of Action: The Matrikine Signaling Cascade
Palmitoyl Tripeptide-1 functions as a biomimetic “matrikine” signal peptide that communicates directly with skin cells to trigger renewal:
1. Fibroblast Activation & Collagen Synthesis
The GHK sequence is a naturally occurring fragment of the Type I collagen C-propeptide
When applied topically, Pal-GHK binds to fibroblast receptors, activating the TGF-β pathway to stimulate fibrillogenesis
Triggers de novo synthesis of Type I and Type III collagen — the most abundant structural proteins of the dermis
At 0.1 μM concentration, upregulates 55% Type I collagen and 48% Type III collagen
2. Extracellular Matrix Rebuilding
Stimulates synthesis of elastin for skin resilience and elasticity
Promotes glycosaminoglycans (GAGs) and hyaluronic acid production for hydration and dermal volume
Increases fibronectin synthesis for cell adhesion and tissue repair
Rebuilds the skin’s support matrix to enhance density, elasticity, and smoothness
3. Anti-Photoaging & MMP Inhibition
Attenuates the inflammatory response to UV radiation, helping prevent collagen breakdown
Protects the skin from UV stimulation
Functions as an antioxidant, combating aging signs and promoting overall skin health
4. Epidermal Regeneration
Promotes epidermal cell regeneration
Supports skin healing and regeneration, improving overall texture and resilience
The palmitoyl (C16) modification is critical for efficacy — it enables the peptide to penetrate the stratum corneum and reach the dermis where fibroblasts reside, achieving deep-layer bioactivity that unmodified GHK cannot deliver.
Clinically Proven Efficacy
Palmitoyl Tripeptide-1 is supported by robust clinical evidence:
| Clinical Finding |
Result |
Study Duration |
| Wrinkle Depth Reduction |
23% reduction |
4 weeks |
| Wrinkle Length Reduction |
39% reduction |
4 weeks |
| Crow's Feet Wrinkle Depth |
32% reduction |
8 weeks (0.1%, twice daily) |
| Type I Collagen Upregulation |
55% increase |
In vitro (0.1 μM) |
| Type III Collagen Upregulation |
48% increase |
In vitro (0.1 μM) |
In a randomized double-blind clinical study, 28 volunteers applied a cream containing Palmitoyl Tripeptide-1 twice daily. Results confirmed significant reductions in wrinkle depth, volume, and density, along with improvements in skin roughness and skin tone uniformity.
Safety Profile: Extensive studies confirm Palmitoyl Tripeptide-1 is non-toxic, non-irritating, and non-sensitizing. It is well-tolerated by all skin types, including sensitive skin.
Key Benefits
| Benefit |
Description |
| Collagen Stimulation |
Upregulates Type I & III collagen synthesis via TGF-β pathway activation |
| Wrinkle Reduction |
Clinically proven 23% reduction in wrinkle depth, 39% reduction in length |
| Skin Firming |
Rebuilds dermal matrix for enhanced density and firmness |
| Elasticity Improvement |
Stimulates elastin and GAG synthesis for improved skin bounce |
| Anti-Photoaging |
Protects against UV-induced collagen degradation |
| Hydration Enhancement |
Promotes hyaluronic acid and GAG production for dermal volume |
| Texture Refinement |
Reduces surface roughness and improves skin tone uniformity |
| Non-Irritating |
Retinol-level anti-aging benefits without irritation or sun sensitivity |
Application Scenarios
| Application |
Typical Formats |
Recommended Usage |
| Anti-Aging Serums & Essences |
Water-based serums, ampoules, concentrates |
≤0.001% – 5% |
| Firming & Lifting Creams |
Day creams, night creams, moisturizers |
≤0.001% – 5% |
| Eye Contour Treatments |
Eye creams, eye serums, eye gels |
≤0.001% – 5% |
| Sheet Masks & Hydrogel Patches |
Face masks, eye patches |
≤0.001% – 5% |
| Barrier Repair Moisturizers |
Advanced moisturizers for barrier strengthening |
≤0.001% – 5% |
| Body Firming Lotions |
Body care for sagging-prone areas |
≤0.001% – 5% |
| Sunscreen Formulations |
Day creams with UV protection |
≤0.001% – 5% |
Formulation Guidelines:
Solubility: Water-soluble; add to the water phase or during cool-down below 40°C
Optimal pH Range: 4.5 – 7.0 for maximum stability
Synergistic Combinations: Pairs exceptionally well with Palmitoyl Tetrapeptide-7 (Matrixyl 3000 complex), hyaluronic acid, vitamin C derivatives, and antioxidants
Recommended Usage: 1% – 5% for standalone formulations; ultra-low concentrations (≤0.001%) also show efficacy
This peptide is widely used in toners, lotions, serums, sun care products, and masks across the global cosmetic market.
Why Choose Our Palmitoyl Tripeptide-1?
✅ Gold-Standard Signal Peptide – Core component of Matrixyl® 3000, the most recognized peptide complex in anti-aging cosmetics
✅ High Purity – ≥98% ensures consistent potency and batch-to-batch reliability
✅ Clinically Proven – 23% wrinkle depth reduction in 4 weeks; 55% Type I collagen upregulation
✅ GHK-Derived Bioactivity – The GHK sequence is nature’s own collagen-building signal, validated by decades of research
✅ Enhanced Penetration – Palmitoyl modification enables deep dermal delivery that unmodified GHK cannot achieve
✅ Excellent Stability – Robust across pH 4.5–7.0 in diverse cosmetic bases
✅ Safe & Non-Irritating – Well-tolerated by sensitive skin; no known adverse effects
✅ Growing Market Demand – Global cosmetic-grade market projected at USD 15.57M (2025), reaching USD 23.47M by 2033 (CAGR 5.26%)
✅ Flexible Packaging – Available in 1g, 1kg, 10kg, and 25kg options with custom packaging available
Packaging & Storage
| Packaging Option |
Specification |
| Sample / Trial |
1g per aluminum foil bag |
| Standard |
1kg per aluminum foil bag |
| Intermediate |
10kg per carton |
| Bulk |
25kg per fiber drum |
| Custom |
Available upon request |
Storage Conditions: Keep sealed, protected from light, and store in a cool, dry, well-ventilated area.
Shelf Life: 24 months from date of manufacture when stored properly.
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