Product Title
Tripeptide-1 (Oligopeptide-1 / GHK) | ≥98% Skin-Identical Matrikine Signal Peptide for Advanced Anti-Aging Formulations
Product Name: Tripeptide-1 / Oligopeptide-1 / GHK
INCI Name: Tripeptide-1
Synonyms: Oligopeptide-1, GHK Tripeptide, Glycyl-L-Histidyl-L-Lysine
CAS No.: 72957-37-0
Molecular Formula: C₁₆H₂₈N₆O₆
Molecular Weight: 400.44 g/mol
Amino Acid Sequence: H-Gly-His-Lys-OH (GHK)
Purity: ≥98%
Appearance: White fine powder
Grade: Cosmetic Grade
Shelf Life: 24 months
Product Overview
Tripeptide-1, also known as Oligopeptide-1 or GHK (Glycyl-Histidyl-Lysine), is a naturally occurring matrikine signal peptide found in human blood, saliva, and skin tissue. It is composed of three amino acids — glycine, histidine, and lysine — and represents one of the most fundamental and well-researched bioactive peptides in cosmetic science.
As a matrikine signal peptide, Tripeptide-1 functions as a "dermal promoting factor" that communicates directly with skin cells to trigger the synthesis of extracellular matrix (ECM) components. When endogenous collagen degrades, similar peptide fragments naturally signal fibroblasts to produce new structural proteins. By supplying this peptide topically, we directly activate this signaling cascade, encouraging fibroblasts to rebuild the dermal matrix.
Tripeptide-1 has been officially included in the China "Catalog of Used Cosmetic Ingredients (2021 Edition)" and is widely recognized for its safety and efficacy. It is the unmodified, skin-identical version of the well-known Palmitoyl Tripeptide-1 (Pal-GHK) — the latter being the lipid-conjugated form for enhanced penetration.
Our Tripeptide-1 is manufactured to ≥98% purity under strict quality control, offering formulators a high-potency, clinically validated active ingredient for premium anti-aging skincare products.
Key Specifications
| Parameter |
Specification |
| Product Name |
Tripeptide-1 / Oligopeptide-1 |
| Synonyms |
GHK, Glycyl-Histidyl-Lysine, Dermal Promoting Factor |
| INCI Name |
Tripeptide-1 |
| CAS No. |
72957-37-0 |
| Molecular Formula |
C₁₆H₂₈N₆O₆ |
| Molecular Weight |
400.44 g/mol |
| Amino Acid Sequence |
H-Gly-His-Lys-OH |
| Purity |
≥98% |
| Appearance |
White fine powder |
| Grade |
Cosmetic Grade |
| Storage |
Sealed, protected from light, stored in cool, dry, well-ventilated area |
| Packaging |
1g/bag, 1kg/aluminum foil bag, custom available |
| Shelf Life |
24 months |
Mechanism of Action: The GHK Signaling Cascade
Tripeptide-1 (GHK) is a matrikine signal peptide that functions through multiple interconnected pathways:
1. Fibroblast Activation & ECM Synthesis
The GHK sequence is a naturally occurring fragment of the Type I collagen C-propeptide
When applied topically, GHK binds to fibroblast receptors, activating signaling cascades that stimulate de novo synthesis of Type I and Type III collagen
Promotes elastin production for skin resilience and elasticity
Stimulates laminin and fibronectin synthesis for cell adhesion and dermal-epidermal junction integrity
Upregulates glycosaminoglycan (GAG) production for hydration and dermal volume
2. Dermal Matrix Rebuilding & Skin Thickening
Acts primarily on the dermis layer to strengthen the skin’s structural foundation
Reinforces the epidermis, resulting in visibly thicker, firmer skin
Helps rebuild the skin’s support matrix to enhance density, elasticity, and smoothness
3. Antioxidant Defense
Enhances the skin’s natural antioxidant capacity
Protects against UV-induced oxidative damage and photoaging
Helps neutralize free radicals that contribute to premature aging
4. Wound Healing & Tissue Regeneration
Supports skin repair and regeneration
Naturally present in human blood and saliva, GHK plays a role in the body’s innate healing processes
Stimulates angiogenesis (new blood vessel formation) to support tissue recovery
5. Epidermal Cell Renewal
Key Benefits
| Benefit |
Description |
| Collagen Stimulation |
Upregulates Type I & III collagen synthesis via fibroblast activation |
| Elastin Production |
Stimulates elastin synthesis for skin bounce and resilience |
| Skin Firming |
Rebuilds dermal matrix for enhanced density and firmness |
| Wrinkle Reduction |
Smooths fine lines and deep wrinkles |
| Antioxidant Protection |
Enhances natural antioxidant capacity and protects against UV damage |
| Skin Thickening |
Reinforces the epidermis and strengthens dermal structure |
| Tissue Regeneration |
Supports wound healing and skin repair |
| Hydration Enhancement |
Promotes GAG synthesis for improved moisture retention |
| Safe & Non-Irritating |
Naturally occurring in the human body; low risk of irritation |
Clinically Recognized Efficacy
Tripeptide-1 is one of the most extensively studied signal peptides in cosmetic science:
| Key Finding |
Mechanism |
| Collagen Synthesis |
Stimulates production of Type I & III collagen via fibroblast activation |
| ECM Rebuilding |
Promotes synthesis of elastin, laminin, fibronectin, and GAGs |
| Antioxidant Capacity |
Enhances skin’s natural defense against oxidative stress |
| Angiogenesis |
Stimulates new blood vessel formation for tissue repair |
| Epidermal Renewal |
Promotes basal cell division and epidermal cell rejuvenation |
Safety Profile: Tripeptide-1 is naturally present in human blood and saliva. It has a low risk of irritation and is considered safe for use in cosmetic formulations. Risk factor rating of 1 (lowest) with no known comedogenicity.
Application Scenarios
| Application |
Typical Formats |
Recommended Usage |
| Anti-Aging Serums & Essences |
Water-based serums, ampoules, concentrates |
0.00002% – 0.001% |
| Firming & Lifting Creams |
Day creams, night creams, moisturizers |
0.00002% – 0.001% |
| Eye Contour Treatments |
Eye creams, eye serums, eye gels |
0.00002% – 0.001% |
| Sheet Masks & Hydrogel Patches |
Face masks, eye patches |
0.00002% – 0.001% |
| Barrier Repair Moisturizers |
Advanced moisturizers for barrier strengthening |
0.00002% – 0.001% |
| Antioxidant Defense Formulations |
Protective day creams, anti-pollution serums |
0.00002% – 0.001% |
| Post-Procedure Recovery Products |
Soothing gels, recovery balms |
0.00002% – 0.001% |
Formulation Guidelines:
Solubility: Water-soluble; add to the water phase or during cool-down below 40°C
Optimal pH Range: 4.5 – 7.0 for maximum stability
Synergistic Combinations: Works synergistically with copper (forming GHK-Cu), hyaluronic acid, and other peptides
Recommended Usage: Extremely low dosage (0.00002%–0.001%) is sufficient due to high potency
This peptide is widely used in serums, creams, lotions, masks, and eye care products across the global cosmetic market.
Packaging & Storage
| Packaging Option |
Specification |
| Sample / Trial |
1g per aluminum foil bag |
| Standard |
1kg per aluminum foil bag |
| Bulk |
Custom packaging available upon request |
Storage Conditions: Keep sealed, protected from light, and store in a cool, dry, well-ventilated area.
Shelf Life: 24 months from date of manufacture when stored properly.
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