Elastin

Advance your tissue repair and regenerative medicine research with our premium Recombinant Human Elastin. As one of the main protein components of the dermal extracellular matrix, elastin plays a critical role in the mechanical behavior and physiological function of the skin, providing essential elasticity and resilience to tissues .

Produced via a precise E.coli expression system, our recombinant elastin overcomes the severe drawbacks of animal-derived elastin, including risk of virus transmission, ready degradation, and challenging quality control .

Key Technical Advantages:

• Thermoresponsive Gelation: Exhibits temperature-sensitive aggregation behavior similar to natural elastin, undergoing phase transition at physiological temperature (37°C) to form a stable hydrogel . This enables minimally invasive injectable applications and in situ scaffold formation.

• Superior Water Solubility: Lyophilized powder readily dissolves in aqueous buffers for convenient formulation.

• Excellent Bioactivity: Significantly promotes the survival and proliferation of human fibroblasts (HFF-1), supporting cellular activity essential for tissue regeneration .

• Ultra-High Purity: >99% via HPLC, free from animal-derived contaminants.

• Controlled Transition Temperature: Engineered sequence ensures reliable and reproducible sol-gel transition at 37°C .

Proven Efficacy:
Studies in mouse models of UV-irradiated skin demonstrate that recombinant elastin hydrogels pronouncedly accelerate the healing process by inhibiting epidermal hyperplasia and boosting the regeneration of both collagen and elastin fibers . Additionally, elastin-enriched scaffolds have shown reduction in α-SMA protein expression (a biomarker of fibrosis) compared to collagen-only scaffolds, indicating potential for scarless healing and reduced wound contraction .

Primary Applications:

• Tissue Repair & Wound Healing: Promotes organized extracellular matrix deposition and reduces scarring.

• Injectable Cell Delivery: Forms cytocompatible hydrogels for minimally invasive cell therapy .

• 3D Cell Culture Scaffolds: Provides a biomimetic microenvironment with tunable mechanical properties.

• Drug Delivery Systems: Enables temperature-controlled release of therapeutic agents.

Supplied as cryo-dried, water-soluble powder in 10g/bag packaging. Ideal for R&D into advanced wound care, dermatology, and tissue engineering applications.